후두유두종의 완치가능성 연구논문 발표
후두유두종의 완치가능성 연구논문 발표
예송이비인후과 음성센터 김형태 원장은 후두유두종 제거 수술 이후의 재발 패턴 발견과 이에 따른 임상적인 치료결과에 대한 연구논문을 이비인후과 분야의 국제학술지 중 가장 권위 있고 최고의 학술지라고 평가 받는 ‘the Laryngoscope’에 논문 발표를 했습니다. 이는 후두유두종의 완치가능성을 알린 최초의 논문입니다.
논문은 지난 8년 4개월 동안 총 86명의 후두유두종 환자를 대상으로 이루어진 연구이며 환자들의 질병 재발 패턴 분석 결과 새로운 수술 방법과 함께 보조치료요법을 병행할 때 후두유두종의 완치 가능성은 높아진다는 결과를 보여주고 있습니다.
연구논문제목 : Is Recurrent Respiratory Papillomatosis a Manageable or Curable Disease?
논문지명 : Laryngoscope, 126:1359–1364, 2016
Objectives: Recurrent respiratory papillomatosis (RRP) is a relatively rare disease with potentially devastating consequences for the patient. The purpose of this study was to evaluate the patterns of recurrence of RRP after surgery and determine the effectiveness of combined concurrent adjuvant therapy.
Methods: A total of 86 patients were diagnosed with and operated on for RRP. The clinical characteristics of 29 of the 86 patients who had undergone operations at other hospitals and who were followed up for >2 years were evaluated retrospectively. A combined concurrent adjuvant therapy was performed with microlaryngeal surgery, 585-nm pulsed dye laser (PDL) application, and an intralesional cidofovir injection. To evaluate the recurrence pattern, the larynx was divided into 10 subsites, and patients were investigated for the frequency of recurrence at the subsites after the operation.
Results: Twenty-nine subjects required a mean of 3.0 operations to achieve complete remission for 2 years. The most common subsites for recurrence were the anterior commissure, subglottis, and epiglottis according to increasing number of operations. The subsites of recurrence tended to be closely correlated with the laryngeal submucosal glandular density distribution. A complete en-bloc layer excision, including the submucosal glands, using cold instruments decreased the recurrence rate of RRP. Applying PDL minimized scarring and provided significant posttreatment voice-quality improvement.
Conclusions: The results of the recurrent pattern analysis suggest that a combined concurrent adjunctive treatment might be promising as a cure for RRP and restoration of vocal function after treatment.